Comparative effect of ozone exposure and 5-aminosalicylic acid in oxazolon-induced colitis upon the indices of innate immunity

Multiple effects of ozone are a prerequisite for its use in the complex therapy inflammatory bowel diseases. Our aim was to analyze and 5-aminosalicylic acid (5-ASA) oxazolone-induced colitis (OIC) upon innate immunity functions.
 OIC modeled 72 male Wistar rats weighing 24020 g by two-stage application oxazolone solution. Ozone at dose 0.05 mg/kg, as part ozone-oxygen mixture, injected intraperitoneally every 24 hours. The laboratory indices were studied on days 2, 4, 6. In blood samples, number leukocytes, differential leukocyte counts, absorptive capacity neutrophils their oxygen-dependent metabolism studied. homogenate colon mucosa, IL-17 concentration measured.
 OIC, 6, leukocytes increased, with predominance lymphocytes, monocytes, absorption capacity; increased areas colonic damage. On 2 activity intensity spontaneous NBT test is like induced NBT-test Administration reduced content along decrease NCT-reducing ability decreased area damage 4 administration if compared 5-ASA, less pronounced respect